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KMID : 1134819960250050871
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Journal of the Korean Society of Food Science and Nutrition
1996 Volume.25 No. 5 p.871 ~ p.877
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Angiotensin I Converting Enzyme Inhibitory Activity of Hot - Water Extract and Enzymatic Hydrolysate of Fresh Water Fish
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Kim Tae-Jin
Yoon Ho-Dong
Lee Doo-Seog
Jang Young-Sun
Seo Sang-Bok
Yeum Dong-Min
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Abstract
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Hot-water extract and enzymatic hydrolysate prepared from fresh water fish such as carp, snakehead, eel and israeli carp were tested for inhibitory activity against Angiotensin I converting enzyme(ACE). ACE inhibitory activity of enzymatic hydrolysate was higher than that of hot-water extract, and was the highest in enzymatic hydrolysate of carp among the tested samples. ACE inhibitory activity of 70% ethanol soluble fraction was higher than that of precipitated fraction, the highest in enzymatic hydrolysate of carp. Molecular weight of active fraction was about 1,400 in hot-water extract and slightly above in enzymatic hydrolysate. Amino acid of active fraction of hot-water extract was abundant in glycine, alanine, leucine and proline, whereas amino acids of aspartic acid, glutamic acid, glycine, alanine, valine, leucine and proline were abundant in enzymatic hydrolysate. IC_(50)(amounts of inhibitors need for 50% inhibition) of hot-water extract was the range of 50.3-56.9μg, those of enzymatic hydrolysate 42.6~57.7μg.
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KEYWORD
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Angiotensin I converting enzyme(ACE), hot-water extract, enzymatic hydrolysate, $IC_{50}$/
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